Fulham manager Martin Jol must decide whether to give ex-Tottenham midfielder Scott Parker his debut against Arsenal.
Goalkeeper Maarten Stekelenburg injured his shoulder at Sunderland so David Stockdale is set to start.
Arsenal's Laurent Koscielny is banned after his sending off against Aston Villa last weekend.
Nacho Monreal is back in the Gunners' squad, but Alex Oxlade-Chamberlain (knee) has joined a lengthy injury list headed by Thomas Vermaelen (back).
The alarm sirens for Arsene Wenger's reign will be screeching if Arsenal lose back-to-back opening league matches for the first time since the inaugural Premier League season 21 years ago.
If they surrender as meekly as they did against Villa then Fulham can record successive opening Premier League victories for the first time.
But the Gunners reminded everyone that they're not far short of being a really good team when they won handsomely at Fenerbahce in the Champions League on Wednesday.
Arsene Wenger has been overly-cautious in the transfer marker so far, but some of the criticism of him has bordered on the hysterical.
Fans have rightly been frustrated that big-name signings have been mooted yet no deals have been forthcoming. But it's not Wenger's fault that Liverpool wouldn't sell Luis Suarez. The Anfield club told us last week the Uruguayan was never going to move to the Emirates.
Yohan Cabaye's smooth passing and movement would add numbers and quality to midfield, a composed defender like Ashley Williams is a must, while a consistently reliable goalkeeper like Asmir Begovic would be an improvement.
A marquee signing up front would also appease the fans - although actually the side already has plenty of potency with four players reaching double figures last season.
Olivier Giroud will always be unfairly compared to Robin van Persie but his 19 goals from 49 games ratio is a decent return. He scored twice in the home game last season against Fulham, who've never won at Arsenal.
Martin Jol has significantly added bite to his midfield with the signing of Scott Parker. The loaning of Darren Bent is also sharp business.
Fulham certainly have enough quality to stay up, although they will have to end their miserable Spring slump at home where they've lost their last four games.
But Fulham's opening win at Sunderland was flattering. The home side dominated possession and had 14 shots. The Cottagers won it with their only effort.
There is also a lack of pace in key areas of Jol's side. Theo Walcott, supplied by Santi Cazorla, can exploit that. It'll be tight and tense but I can't see Arsenal being beaten again.
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